Richard M Weinshilboum Selected Research

Cytochrome P-450 CYP2D6 Inhibitors

11/2011	Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials.
1/2005	CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.

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Richard M Weinshilboum Research Topics

Disease

50	Breast Neoplasms (Breast Cancer) 06/2022 - 08/2003
22	Neoplasms (Cancer) 06/2022 - 03/2006
15	Major Depressive Disorder (Major Depressive Disorders) 11/2022 - 03/2013
6	Drug-Related Side Effects and Adverse Reactions 11/2017 - 03/2004
4	Inflammation (Inflammations) 01/2019 - 01/2017
3	Triple Negative Breast Neoplasms 06/2022 - 01/2018
3	Bipolar Disorder (Manic Depressive Psychosis) 12/2021 - 12/2020
3	T-Cell Leukemia (Leukemia, T Cell) 01/2018 - 03/2012
3	Carcinogenesis 12/2007 - 03/2002
2	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 01/2018
2	Leukopenia 01/2022 - 01/2015
2	Ulcerative Colitis 10/2020 - 07/2002
2	Neutropenia 01/2018 - 01/2015
2	Musculoskeletal Pain 03/2016 - 03/2012
2	Hypertension (High Blood Pressure) 02/2015 - 01/2014
2	Disease Susceptibility (Diathesis) 02/2015 - 11/2006
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2015 - 12/2010
2	Colorectal Neoplasms (Colorectal Cancer) 01/2013 - 07/2007
2	Lung Neoplasms (Lung Cancer) 03/2010 - 04/2006
1	Fatigue 11/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Cardiotoxicity 01/2022
1	Rheumatoid Arthritis 01/2022
1	Alcoholism (Alcohol Abuse) 01/2022
1	Heart Failure 01/2022
1	Depressive Disorder (Melancholia) 01/2020
1	Amenorrhea 10/2019
1	Obesity 01/2019

Drug/Important Bio-Agent (IBA)

18	Pharmaceutical PreparationsIBA 06/2022 - 01/2006
18	Aromatase InhibitorsIBA 10/2021 - 12/2005
16	Estrogens (Estrogen)FDA Link 01/2022 - 03/2002
11	Anastrozole (Arimidex)FDA LinkGeneric 01/2022 - 01/2010
10	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2021 - 01/2005
10	Tamoxifen FDA LinkGeneric 01/2021 - 01/2005
10	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 07/2002
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2017
9	Estrogen ReceptorsIBA 01/2020 - 01/2013
7	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 01/2013 - 01/2005
6	Aromatase (CYP19)IBA 01/2020 - 12/2005
6	EnzymesIBA 11/2011 - 01/2005
5	exemestane (Aromasin)FDA Link 01/2022 - 12/2016
5	Estradiol (Delestrogen)FDA LinkGeneric 01/2020 - 01/2010
5	Selective Estrogen Receptor Modulators (SERM)IBA 08/2017 - 11/2011
4	Hormones (Hormone)IBA 10/2021 - 08/2003
3	Long Noncoding RNAIBA 12/2021 - 12/2016
3	Antidepressive Agents (Antidepressants)IBA 01/2021 - 01/2005
3	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 01/2015
3	Estrone FDA Link 01/2020 - 01/2010
3	Citalopram FDA LinkGeneric 01/2019 - 08/2014
3	Escitalopram FDA Link 01/2019 - 08/2014
3	Bevacizumab (Avastin)FDA Link 01/2018 - 12/2015
3	Gemcitabine FDA Link 06/2010 - 03/2006
2	AnthracyclinesIBA 01/2022 - 01/2018
2	Methotrexate (Mexate)FDA LinkGeneric 01/2022 - 01/2015
2	abirateroneIBA 01/2022 - 01/2018
2	Letrozole (Femara)FDA LinkGeneric 01/2022 - 01/2020
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021 - 12/2020
2	afimoxifene (hydroxytamoxifen)IBA 06/2019 - 10/2009
2	CytokinesIBA 01/2019 - 03/2012
2	Biological ProductsIBA 10/2018 - 01/2018
2	Cytochrome P-450 CYP3AIBA 01/2018 - 01/2005
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2018 - 01/2015
2	P-2 (P 2)IBA 01/2017 - 07/2013
2	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 01/2015 - 12/2010
2	Raloxifene Hydrochloride (Evista)FDA Link 07/2013 - 11/2011
2	Cytochrome P-450 CYP2D6 InhibitorsIBA 11/2011 - 01/2005
2	pyrimidineIBA 11/2011 - 07/2007
2	purineIBA 11/2011 - 07/2007
2	Acetaminophen (Paracetamol)FDA LinkGeneric 03/2011 - 03/2008
2	2-mercaptopurineIBA 12/2010 - 03/2004
2	CytidineIBA 06/2010 - 11/2009
2	4-hydroxy-N-desmethyltamoxifenIBA 06/2010 - 10/2009
2	PlatinumIBA 03/2010 - 04/2006
2	Glutathione (Reduced Glutathione)IBA 03/2010 - 04/2006
2	Antineoplastic Agents (Antineoplastics)IBA 06/2008 - 12/2007
1	Fluoxetine (Prozac)FDA LinkGeneric 11/2022
1	Duloxetine Hydrochloride (Cymbalta)FDA Link 11/2022
1	Androgen Receptors (Androgen Receptor)IBA 06/2022
1	Phenobarbital (Luminal)FDA Link 06/2022
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 01/2022
1	Acamprosate (Campral)FDA Link 01/2022
1	Trastuzumab (Herceptin)FDA Link 01/2022
1	UbiquitinIBA 01/2022
1	Codon (Codons)IBA 01/2022
1	sacubitril and valsartan sodium hydrate drug combinationIBA 01/2022
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	GlucocorticoidsIBA 12/2021
1	anemoside B4IBA 10/2020
1	LigandsIBA 01/2020
1	acylcarnitineIBA 01/2020
1	Fulvestrant (Faslodex)FDA Link 01/2020
1	Serotonin (5 Hydroxytryptamine)IBA 01/2020
1	Docetaxel (Taxotere)FDA Link 06/2019

Therapy/Procedure

27	Therapeutics 06/2022 - 01/2005
14	Drug Therapy (Chemotherapy) 01/2022 - 07/2007
5	Neoadjuvant Therapy 06/2022 - 01/2010
2	Castration 01/2022 - 01/2018
2	Chemoprevention 01/2017 - 11/2011
1	Complementary Therapies (Alternative Medicine) 01/2022
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 10/2020